Roche Postdoctoral Fellow (RPF) in Cancer Immunotherapy

The Position

In Roche's Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world's toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The position 

As a cross-department Postdoctoral Fellow, you will focus on exploratory research projects aimed to characterize, implement and validate human colorectal cancer organoids model systems for their use in the development, screening and Mode of Action (MoA) understanding of next-generation cancer immunotherapy molecules. 

We are looking for a highly motivated candidate to join our cross-functional team in order to strengthen the use of Patient-Derived Tumor Organoids (PDTOs). You will be responsible for setting up and validating PDTOs co-cultures with TME stromal components. 

In this position, you will:

• Perform cutting edge science using Patient-Derived Tumor Organoids for the assessment of molecules MoA

• Design, prepare and execute experiments and data interpretation

• Communicate scientific progress through internal meeting and publications

• Collaborate and interact with several departments, including Cancer Immunotherapy, Pharmacology and Institute of Human Biology

• Commit to work with a proactive mindset and in close collaboration with a team of experts and project members in order to effectively advance projects

• Work with human tumor cell lines

• Conduct in-vitro characterization of the activity of novel immunotherapies

Ideally, you have experience and expertise in the following:

• Hold a PhD in Cancer Immunology obtained no longer than four years ago

• Have a track record of hands-on experience with Organoids (possibly Patient Derived Tumor Organoids)

• Hands-on experience with mammalian cell culture

• Hands-on experience with Multiparametric Flow Cytometry

• Expertise in confocal imaging is a plus

• Expertise in data analysis (scRNAseq) is a plus

You have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies.

You have been actively engaged in scientific research continuously since your PhD (MD or MD/PhD) and ready to start a postdoctoral activity.
 

The preferred start date of the internship is August 2023, or upon availability, for a duration of three years. Please clearly indicate your preferred starting date on your motivation letter. All applications always need to include a CV, motivation letter, a publication list and, if available, your PhD certificate.

This position is sponsored by the Roche Postdoctoral Fellowship Program. 

The RPF Program has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world. One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals, if necessary preceded by priority patent applications.

The duration of the RPF project is initially set for two years, with the possibility of extension for a third year. You will be based at the Roche site located in Zürichwith possibility to visit the Roche site located in Basel based on project needs. 

If you are proud of contributing and feel you have the dedication to teamwork and innovation that we are seeking, then Roche is the organization for you. Every role at Roche plays a part in making a difference in patients' lives. If you want to work in a passionate team, make your mark, improve lives, apply now.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

The Roche Innovation Center Zurich (Roche Glycart AG) is active in the research and development of engineered therapeutic antibodies, with a focus on the fields of cancer immunotherapy. Part of the Roche Group since 2005, it currently employs about 140 people. Read more.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.