Roche Postdoctoral Fellowship, Disease Modeling In Human Intestinal Organoids (m/f/d)

 

The Position

At Roche Pharmaceutical Research and Early Development Organization (pRED), we believe that rapid advances in science and technology are our greatest opportunity to rethink the way we address some of the world's most challenging unmet health needs and have an even more profound impact on patients and society.

We are seeking an independent and highly motivated postdoctoral fellow to join the Multi-Tissue Systems Engineering and Organoid Engineering, teams. This is a unique and exciting opportunity to work at the Roche Institute for Translational Bioengineering (ITB; http://ritb.roche.com), a scientific group within pRED whose goal is to disrupt the traditional drug development process through big and bold ideas to develop more predictive human model systems.

The postdoctoral fellow will play a key role in ITB's efforts to develop and apply next-generation human model systems that preserve important functional features of organ and disease biology outside the patient.

Your responsibilities are:

  • Collaborate with internal and external partners to drive projects aimed at replicating the key functional hallmarks of healthy and diseased intestinal tissues

  • Apply cutting-edge bioengineering (and, in particular, biofabrication) approaches to enhance the pathophysiological relevance of organoid models, facilitating breakthroughs in understanding and treating complex, multifactorial diseases.

  • Apply advanced phenotyping technologies to characterize organoid models, increase their pathophysiological relevance, and expand their translational value

  • Work closely with ITB colleagues in the areas of microtechnology, organoid development, and phenotyping to address complex scientific and technological challenges

  • Collaborate with Roche preclinical and clinical experts to drive the validation and implementation of advanced organoid models in early drug development

  • Generate high-quality results for peer-reviewed publications and present at scientific conferences

Who you are:

You are a biologist with a Ph.D. (or close to finishing your Ph.D. degree) in the field of organoid biology/technology with a profound understanding of cell and/or developmental biologyYou graduated from your Ph.D. program no more than 4 years ago. Furthermore, you are intellectually brave and adept at applying your skills to new fields to generate innovative and transformative insights. Your experience and investigative attitude allow you to work independently, design, perform, and interpret experiments, and embark on new scientific methodologies.

The position would require advanced expertise in the following:

  • Human intestinal stem cell culture  

  • Biology and technology of human intestinal (small intestine and colon) organoids, derivation, and culture

  • Processing of primary tissue samples to isolate key cell types

  • Application of microfluidics and organs-on-chip/microphysiological systems

  • Histological techniques (fixation, clearing, staining, and tissue sectioning)

  • Basic molecular and cell biology techniques

  • Multicolor microscopy, image processing, and analysis

  • Immunophenotyping by flow cytometry

The following experiences would be considered an asset:

  • Sample preparation, generation, analysis, and interpretation of single-cell and spatial omics (transcriptomics, proteomics) data

  • Disease modeling

To be considered, your application needs to include the following:

  • A cover letter, a CV (including a list of relevant publications), and the names of three references

The start date of this fellowship is as soon as possible or upon availability.

Have we piqued your interest? We look forward to receiving your application.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

Roche
Roche ist ein globales Unternehmen mit Vorreiterrolle in der Erforschung und Entwicklung von Medikamenten und Diagnostika und ist darauf fokussiert, Menschen durch wissenschaftlichen Fortschritt ein besseres, längeres Leben zu ermöglichen. Roche ist das grösste Biotech-Unternehmen weltweit mit differenzierten Medikamenten für die Onkologie, Immunologie, Infektionskrankheiten, Augenheilkunde und Erkrankungen des Zentralnervensystems. Roche ist auch der bedeutendste Anbieter von In-vitro-Diagnostika und gewebebasierten Krebstests und ein Pionier im Diabetesmanagement. Dank der Kombination von Pharma und Diagnostika unter einem Dach ist Roche führend in der Personalisierten Medizin – einer Strategie mit dem Ziel, jedem Patienten die bestmögliche Behandlung zukommen zu lassen.
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