The Position
At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare.
We believe it's urgent to deliver medical solutions right now - even as we develop innovations for the future. We are passionate about transforming patients' lives and we are fearless in both decision and action. And we believe that good business means a better world.
We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.
The position
Pharmaceutical Sciences (PS) is a global function within Roche Pharma Research and Early Development (pRED). As a team member in Predictive Modelling and Data Analytics (PMDA) chapter of PS, you will work in close collaboration with scientists in pRED, using state-of-the-art bioinformatics and biostatistics tools and methods. You will focus on exploratory research project focused on the integration of microbiome and human genetics data across different disease indications.
In this position you will:
Investigate genetic data of disease and healthy individuals.
Implement microbiome data analysis.
Integrate metagenomics and human genomics data through the use of various computational tools and, in particular, develop Mendelian Randomization (MR) methods and the use of Polygenic Risk Scores (PRS).
Apply combined analysis of genomic and microbiome data to better understand their interplay in the context of disease areas of Roche's interest (immunology, oncology and neuroscience) and contribute to the better understanding of the disease biology.
Collaborate with biologists, geneticists and clinicians and proactively share learnings and knowledge to support the development of the wider Roche community.
One of the key aims of the position is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals, if necessary preceded by priority patent applications.
The duration of the position is set for two years. You will be based in Basel, Switzerland.
You are a computational biologist with a postgraduate scientific degree (PhD) in the field of human genomics and/or metagenomics.
You also have experience and expertise in the following:
Python, R or at least one programming language
Advanced statistics, causal inference and, favorably, machine learning methods
Working with bioinformatics tools and methods
Experience and expertise in the following counts as a plus:
Biology in one of the disease indications of Roche interests (oncology, immunology, neuroscience)
Dealing with genomics large scale cohort data (e.g., UK BioBank)
Strong experience with metagenomics tools and microbiome data
You have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies.
You have been actively engaged in scientific research continuously (documented through publication co-authorships) and ready to start a postdoctoral activity having obtained your PhD no later than 4 years ago.
When does it start?
The start date of this fellowship is Q3 2022, or on availability. In case of specific preferences, please indicate your preferred starting date in your motivation letter.
All applications need to include a CV (with a publication list) and a motivation letter.
Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq
Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.
Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.
We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.
Roche is an Equal Opportunity Employer.
Job Level:
Entry Level
