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The department of Investigative Safety at the Roche Innovation Center Basel focuses on creating and applying advanced human cellular models to support preclinical drug safety assessment and the elucidation of drug toxicity mechanisms.
You responsibilities are
Independently drive a project to create next-generation immune-competent models of mucosal tissues, with a focus on the intestine, by combining primary human samples, organoids and Organs-on-Chips to recreate the cellular environment of real organs.
Collaborate with our multidisciplinary teams to improve the capacity of cell-based systems to 1) predict cancer immunotherapy-induced adverse events in patients, 2) understand the underlying molecular and cellular mechanisms, 3) identify strategies to evade them, and 4) elucidate the factors that govern variability in patient response.
Generate high-quality results for peer-reviewed publications and present at scientific meetings
Who You Are
You are a scientist with a PhD in the field of immunology or immuno-oncology with profound understanding of mucosal immunology. Furthermore, you have great interpersonal and communication skills. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies. The position would require advanced expertise in:
Multi-color microscopy and immune phenotyping by flow cytometry (>12 markers)
Basic immunological assays
Isolation of peripheral and tissue-resident immune cells
Primary cell cultures and basic molecular and cell biology techniques
The following experiences would be considered an asset
3D culture (e.g. organoids, spheroids)
Isolation of epithelial cells from human tissues including cell sorting
Generation, analysis and interpretation of scRNAseq data
Cancer immunotherapy
The preferred start date is April 1, 2021.
To be considered your application needs to:
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Are you ready to apply? We are looking for someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche. When applying for this position, already project yourself in the future. Think about what could come next and how you would like to build your future.
Roche embraces diversity and equal opportunity in a serious way. We are dedicated to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
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